REGRESSION OF CORONARY ATHEROSCLEROSIS IN DIABETIC PATIENTS WITH HIGH INTESITY STATIN REGIMENS: INSIGHTS FROM SATURN
نویسندگان
چکیده
منابع مشابه
High-intensity statin therapy alters the natural history of diabetic coronary atherosclerosis: insights from SATURN.
OBJECTIVE Although statins can induce coronary atheroma regression, this benefit has yet to be demonstrated in diabetic individuals. We tested the hypothesis that high-intensity statin therapy may promote coronary atheroma regression in patients with diabetes. RESEARCH DESIGN AND METHODS The Study of Coronary Atheroma by Intravascular Ultrasound: Effect of Rosuvastatin Versus Atorvastatin (SA...
متن کاملA study of iron status in patients with coronary atherosclerosis
Background: It has been demonstrated that free oxygen radicals have a close interaction with lipid peroxidation, causing a modification of low-density lipoproteins (LDL) and facilitating LDL deposition, with the consequent formation of atherosclerosis plaques. Free radical production is catalyzed and accelerated in the presence of iron. This study was conducted to evaluate the possible associ...
متن کاملEffect of very high intensity statin therapy on regression of coronary atherosclerosis.
CONTEXT Prior intravascular ultrasound (IVUS) trials have demonstrated slowing or halting of atherosclerosis progression with statin therapy but have not shown convincing evidence of regression using percent atheroma volume (PAV), the most rigorous IVUS measure of disease progression and regression. OBJECTIVE To assess whether very intensive statin therapy could regress coronary atheroscleros...
متن کاملLong-term effects of maximally intensive statin therapy on changes in coronary atheroma composition: insights from SATURN.
AIMS To evaluate the effect of long-term maximally intensive statin therapy on indices of coronary atheroma composition in a randomized trial, and how these changes relate to modifications of serum lipoproteins and systemic inflammation. METHODS AND RESULTS The Study of coronary Atheroma by inTravascular Ultrasound: the effect of Rosuvastatin vs. atorvastatiN (SATURN) employed serial intravas...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2013
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(13)61129-8